Molecular advances in QTL discovery and application in pig breeding

摘要

Thousands of quantitative trait loci (QTL) have been identified for a wide range of economically important phenotypes in pigs. Recently, QTL analyses have begun to use high-density single nucleotide polymorphism (SNP) panels and applications have extended beyond experimental intercrosses to outbred populations by exploiting long-range linkage disequilibrium that results in higher resolution QTL mapping. Relevant phenotypes generally fall under categories of growth and body composition, carcass and meat quality, reproduction, and disease resistance. A few expression QTL (eQTL) studies have been performed that integrate transcriptional profiles with genotype data by considering expression levels as response variables in OIL analyses for identifying genes controlling important trait phenotypes. Rapidly evolving genomics technologies, including RNAseq, provide tremendous opportunities for QTL and eQTL discovery. In this review, we discuss recent progress in pig QTL and eQTL discovery, including approaches for allele-specific expression, and implications of these discoveries for pig breeding and genetics.