Toward In vivo digital synchronous sequential circuits

摘要

We present the model of a first digital synchronous sequential circuit, i.e. 1-bit synchronous counter, which is about to be realized within the living cell. Mathematical model was constructed upon gene expression based logic with ordinary differential equations (ODEs), particularly Hill equations. The behaviour of the counter was simulated in Mat lab/Simulink environment. With the promising simulation results presented in the paper physical realization of the circuit described within the living cell can be initiated. Introduction of synchronization with a special signal, i.e. clock signal, brings many benefits to the field. Realization of such circuit would therefore present an important step toward the construction of complex biological information processing capable systems.