FAME, a novel conditioning regimen for allogeneic stem cell transplantation for lymphoma, does not earn fame

摘要

Allogeneic hematopoietic stem cell transplantation(HSCT) is an established treatment for hematologicalmalignancies. The procedure starts with a conditioningregimen to eradicate malignant cells and to suppress the hostimmune system to ensure engraftment of donor stem cells.Cyclophosphamide combined with either busulfan or totalbody irradiation has been established as a standard regimenfor allogeneicHSCT for leukemia.On the other hand, there isno standard conditioning regimen in allogeneic HSCT forlymphoma. Although the BEAM regimen, a combination ofcarmustine, etoposide, cytarabine, and melphalan, has beenestablished as an effective conditioning regimen forautologous HSCT for lymphoma, there are concernsregarding its immunosuppressive effect to ensure donor cellengraftment when used for allogeneic HSCT [1].