Reduced-intensity conditioning allogeneic transplant in heavily pre-treated chronic lymphocytic leukaemia patients: A single centre experience

摘要

B-cell chronic lymphocytic leukemia (B-CLL) is a lymphoproliferative disorder characterized by a heterogeneous clinical course that can be predicted by an array of new biological prognostic parameters [1-4]. Despite recent therapeutic advances (mainly based on the combination of immuno and chemotherapy) the only curative option, especially for high-risk CLL patients, is represented by allogeneic transplantation [5,6]. However, overall mortality in allotransplanted CLL patients who undergo myeloablative conditioning regimens ranges between 30 and 60% [7,8].