Preparation of silica nanoparticles from organic laboratory waste of silica gel HF254 and their use as a highly efficient catalyst for the one-pot synthesis of 2,3-dihydro-1H-isoindolone derivatives

摘要

Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between 6-formyl-2,3-dimethoxybenzoic acid and secondary amines (dibenzyl- or benzyl(isopropyl)amine) in the presence of silica nanoparticles (silica NPs, ca. 70 nm) proceeds smoothly at room temperature to afford 2,3-dihydro-1H-isoindolone derivatives in high yields.