Synthesis and Transformation of Methyl 2-(6-Hydroxy-2-phenyl-pyrimidin-4-yl)acetate:Simple Preparation of Pyrimidines with Heterocyclic Substituents

摘要

A simple and efficient synthesis of four new substituted pyrimidines,compounds 9a-d,from the title compound 3 is described.Conversion of 3 to methyl(E)-3-(dimethylamino)-2-(6-methoxy-2-phenyl-pyrimidin-4-yl)prop-2-enoate(4),followed by condensation with various dinucleophiles according to the 'enaminone methodology',afforded the target compounds 9 in medium-to-good yields.