Effect of prolonged formalin fixation on immunohistochemical staining for the proliferation marker Ki67.

摘要

Sir: I read with interest the report by Ip et al.1 on Rosai-Dorfman disease-like changes in mesenteric lymph nodes secondary to Salmonella infection. For the sake of fairness, I would like to point out that similar changes had been described by Story and Hanbury2 as early as 1957, and that A. Templeton, at the time Pathologist-in-Chief of Makerere University Hospital, Kampala, Uganda, suggested to me in 1961 the possibility of Rosai-Dorfman disease being a form of salmonellosis, in view of the morphology of the histiocytes and the lymphophagocytosis.