Vibrational circular dichroism: A valuable tool for conformational analysis and absolute configuration assignment of chiral 1-aryl-2,2,2-trifluoroethanols

摘要

Vibrational circular dichroism spectra allow one to assign the absolute configuration and to monitor the conformational equilibria related to CF _3?OH hydrogen bonding of [2.2]paracyclophane with an external stereogenic carbon atom bearing CF_3, OH and H (see picture).