G-protein-coupled receptor kinases in hypertension

摘要

G-protein-coupled receptors (GPCRs) are one of the most important classes of proteins in living organisms. The pioneer studies of Brian Kobilka (from Stanford University) and Robert Lefkowitz (from Duke University) led to breakthroughs that have opened the way to a detailed dissection of the mechanisms of GPCR function and made them recently earn the 2012 Nobel Prize in Chemistry.