A Comparative Study of Damage to Liver Function after TACE with Use of Low-dose versus Conventional-dose of Anticancer Drugs in Hepatocellular Carcinoma

摘要

Background/Aims: To study liver function damage after transcatheter arterial chemoembolization (TACE) with use of low-dose versus conventional-dose anticancer drugs in patients with hepatocellular carcinoma (HCC).Methodology: One hundred and twelve patients with unresectable HCC were randomly divided into two groups to receive superselective TACE. Patients in group A (n=52) received low-dose anticancer drugs: mitomycin C (MMC) 2~8mg, epirubicin (EPI) 5~10mg and carboplatin (CBP) l00mg were used. Patients in group B (n=60) were given conventional-dose of anticancer drugs (MMC l0mg, EPI 40mg, CBP 300mg). Lipiodol-anticancer drugs emulsion was injected into the feeding arteries of tumors followed by gelatin sponge (GS) or polyvinyl alcohol (PVA) particles embolization. Liver function wasevaluated with Child-Pugh scores, total bilirubin (TBIL), albumin (ALB) and alanine aminotrans-ferase (ALT) before TACE, three days, one week (wk) and four wk after procedures. Results: In both groups, TBIL, ALT, and Child-Pugh scores increased (P<0.001 or P<0.05) and ALB decreased (P<0.001 or P<0.01) three days and one wk after TACE. The different between the parameters obtained four wk after the procedure and baseline parameters was not significant in group A (P>0.05). In group B, however, significant difference (P<0.05) was found in all parameters except ALT. Conclusions: Superselective TACE with use of low-dose anticancer drugs induces transient impairment in liver function, but use of conventional-dose anticancer drugs can cause lasting, more serious worsening of liver function.