Chiral Amino Amides for the Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation Reaction of Ketones in Water

摘要

The chiral amino amide 3 was derived from L-proline and used for the [RuCl2(p-cymene)](2)-catalyzed asymmetric transfer hydrogenation of prochiral ketones performed in water. Moderate to good chemical selectivities (up to 95% yield) mid enantioselectivities (up to 90% ee) were obtained in the presence of 2 mol % of TBAB (n-Bu4NBr) as the phase transfer catalyst.