Context.-Serum concentrations of gonadal hormones have been associated with various measures of well-being, but it is unclear whether their association with mood is confounded by concurrent physical morbidity. Objective.-To determine whether the association between serum testosterone concentration and mood in older men is independent of physical comorbidity. Design.-Cross-sectional study. Setting.-Community of Perth, Western Australia. Participants.-A community sample of men aged 71 to 89 years. Main Outcome Measures.-We used the 15-item Geriatric Depression Scale (GDS-15) to assess depressed mood. Clinically significant depression was defined a priori as a GDS-15 score of 7 or greater. Physical health was assessed using the weighted Charlson index and the Physical Component Summary score of the 36-Item Short Form Health Survey.
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