New high selective sorbents for solid-phase extraction.Molecular imprinted polymers

摘要

In the last few years solid-phase extraction (SPE) has become the most often used preconcentration technique for trace analysis. In SPE with most commercial sorbents, many components of complex samples are co-extracted, so additional clean-up is usually needed before the chromatographic analysis is made. However, specific SPE materials avoid this problem by providing a selective extraction. So far, the most selective phases used for SPE are based on immunoaffmity (IAC). The high selectivity and low stability of immunosorbents and the fact that is difficult and expensive to obtain biological antibodies are reason that lACs are used less widely for many different compounds. An alternative technology, using molecular-ly imprinted polymers (MIPs), is currently being extensively evaluated. Table 1 compares characteristics of molecularly imprinted polymer, immunoaffinity and conventional SPE columns.