Effects of striatal ΔFosB overexpression and ketamine on social defeat stress-induced anhedonia in mice.

摘要

This study found that CSDS triggers persistent anhedonia and confirms that ΔFosB overexpression produces stress resilience. The findings of this study also indicate that acute administration of ketamine fails to attenuate CSDS-induced anhedonia despite reducing other depression-related behavioral abnormalities.