HPV screening for cervical cancer in rural India: do we have an answer?

摘要

This randomized clinical trial was conducted to study the impact of a single round of screening using human papillomavirus (HPV) testing on the incidence of and mortality from cervical cancer. The study enrolled 131 746 women living in 497 villages in Osmanabad district, Maharashtra, India. The study population was divided into 52 clusters and randomized into 4 groups (each with 13 clusters). Three groups were screened for cervical cancer using one of the following methods-HPV testing by the Hybrid Capture 2 (hc2) test (Qiagen Gaithersburg Inc., USA), conventional cervical cytology or VIA (visual inspection with acetic acid); and the fourth (control) group was given standard care.