Total intravenous anaesthesia with propofol-racemic ketamine and propofol-S-ketamine: A comparative study and haemodynamic evaluation in dogs undergoing ovariohysterectomy

摘要

Total intravenous anaesthesia (TIVA) with propofol and ketamine proved to be very satisfactory from a clinical point of view. This blind randomised controlled trial was designed to compare induction and maintenance of anaesthesia under continuous infusion of propofol-racemic ketamine (PRK) with that of propofol-S-ketamine (PSK) and evaluate their haemodynamic, metabolic and ventilatory effects. Seven female dogs undergoing ovariohysterectomy were involved in each group. Anaesthesia was induced: in Group PRK, with propofol (4.0mg kg~(-1) ) and racemic ketamine (2.0mg kg~(-1) ) intravenous (i.v.), followed by hv. infusion of propofol (initial dose of 0.5mg kg~(-1) min~(-1) ) and racemic ketamine (0.2mg kg~(-1) min~(-1) ); in Group PSK, with propofol(4.0mg kg~(-1) ) and S-ketamine (1.0 mg kg~(-1) ) i.v., followed by i.v. infusion of propofol (initial dose of 0.5mg kg~(-1) min~(-1) ) and S-ketamine (0.1 mg kg~(-1) min~(-1) ). Parameters were assessed before anaesthesia and in 6 time points after induction. In both groups, heart rate increased significantly at all time points. There was a slight decrease in systemic blood pressure, cardiac output and cardiac index in both groups. The systolic index decrease significantly and intense respiratory depression was observed in all groups, making assisted ventilation necessary.