Trace minerals status and antioxidative enzyme activity in dogs with generalized demodecosis.

摘要

The present study was aimed to determine the levels of trace elements zinc, copper, iron, erythrocyte oxidant/anti-oxidant balance, vitamin C and beta -carotene in dogs with generalized demodecosis. A total of 24 dogs with clinically established diagnosis of generalized demodecosis and 6 dogs as control were included in the study. In comparison to healthy control, zinc and copper levels were significantly (P<0.01) lower in dogs with generalized demodecosis, whereas iron levels were significantly (P<0.01) higher. Malondialdehyde (MDA) levels were significantly (P<0.01) higher in diseased dogs whereas activity of superoxide dismutase (SOD) and catalase were significantly (P<0.01) lower. beta -carotene and vitamin C levels were significantly (P<0.05) lower in diseased dogs when compared to healthy control. SOD activity was positively correlated with zinc (r_s=0.65, r_s=0.71 and P<0.05) and copper (r_s=0.51, r_s=0.63 and P<0.05) in both healthy and diseased dogs. MDA levels were negatively correlated with iron (r_s=-0.49, r_s=-0.78 and P<0.05), beta -carotene (r_s=-0.26, P>0.05; r_s=-0.54, P<0.05, respectively) in both healthy and diseased dogs and with SOD activity in diseased dogs only (r_s=-0.68, P<0.05). From the present study, it was concluded that generalized demodecosis in dogs is associated with significant alteration in trace elements and oxidant/anti-oxidant imbalance and this imbalance might be secondary to changes caused by demodectic mange.