Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival.

摘要

In this study 1016 patients were screened for the presence of circulating donor-specific anti-HLA antibodies and their complement-binding capacity. Patients with complementbinding donor-specific anti-HLA antibodies after transplantation had the lowest 5-year rate of graft survival (54%), as compared with patients with non-complementbinding donor-specific anti-HLA antibodies (93%) and patients without donor-specific anti-HLA antibodies (94%) (P<0.001 for both comparisons) (1, 2).