Ineffective VTA Disinhibition in Protracted Opiate Withdrawal

摘要

Recently, Kaufling and Aston-Jones showed that, under protracted opiate withdrawal, control of dopamine activity by the tail of the ventral tegmental area shifts from a bidirectional influence towards one-way inhibition. Beyond dysphoric states accompanying withdrawal, these results may also impact research on depression and individual differences in coping and affect.