BEND3 mediates transcriptional repression and heterochromatin organization

摘要

Transcription repression plays a cen-tral role in gene regulation. Transcription repressors utilize diverse strategies to mediate transcriptional repression. We have recendy demonstrated that BEND3 (BANP, E5R and Nacl domain) protein represses rDNA transcription by stabilizing a NoRC component. We discuss the role of BEND3 as a global regulator of gene expression and propose a model whereby BEND3 associates with chromatin remodeling complexes to modulate gene expression and heterochromatin organization.