Short duplication within the RHCE gene associated with an in cis deleted RHD causing a Rh-null amorph phenotype in an immunized pregnant woman with anti-Rh29

摘要

BackgroundThe rare amorph Rh-null phenotype is caused by silent alleles at the RH locus and usually arises in consanguineous families. To date, only five molecular backgrounds have been identified in five unrelated families. Subjects with Rh-null red blood cells (RBCs) readily produce alloantibodies to high-prevalence Rh antigens.