Pulmonary adverse events in unrelated donors of peripheral blood stem cells

摘要

Short-term treatment with recombinant human granulocyte colony-stimulating factor (rhG-CSF) followed by leukapheresis (LPH) is the common procedure for obtaining CD34+ peripheral blood progenitor cells from allogeneic donors. Bone pain, headache and flu-like symptoms are well-known G-CSF-associated side effects that occur for a short duration. In addition, fatigue and gastrointestinal or cardiovascular symptoms may also be observed, but these are rare complications. D'Souza etal. (2008) reported on the different adverse events experienced by healthy donors after stimulation with rhG-CSF, of which pulmonary toxicity was a prominent finding. Here, we report two cases of healthy donors with lung injury and interstitial pneumonia, respectively, and haemoptysis. A 31-year-old woman, who was an unrelated donor, received G-CSF (lenograstim, 8.5 mug kg~1 day~1) over 5 days, without unexpected adverse events, for peripheral blood stem cell mobilisation. The white blood cell (WBC) count at the time of LPH (day 0) was 39.9 x 109 L~1 Three days after LPH (day 3), she experienced symptoms of common cold.