Brimonidine is a selective alpha-2-adrenergic agonist used to treat glaucoma. We report a case of a 9-day-old female who developed, 90 minutes after accidentai ingestion of 3 eye drops of 0.2% brimonidine, coma, apnea, hyperglycemia and miosis requiring intubation and mechanical ventilation. Plasma concentration, 3 hours after intake, was 11.7 ng/mL Normal consciousness was reached after 27 hours. Apnea recovered slowly, normal breath was reached 47 hours after accidentai intake. This report adds to the existing evidence that brimonidine has serious systemic effects in newborns and can require fast and supportive management in intensive care unit.
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机译：溴莫尼定是一种用于治疗青光眼的选择性α-2-肾上腺素能激动剂。我们报告了一例9天大的女性，在意外摄入3滴0.2％溴莫尼定滴眼液，昏迷，呼吸暂停，高血糖和瞳孔缩小，需要插管和机械通气后90分钟发育。摄入后3小时的血浆浓度为11.7 ng / mL，27小时后达到正常意识。呼吸暂停缓慢恢复，意外摄入后47小时达到正常呼吸。该报告增加了现有证据，表明溴莫尼定在新生儿中具有严重的全身作用，可能需要在重症监护室进行快速和支持性处理。
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