Characterization of two new human leukocyte antigen class I alleles B*0829 and Cw*0736.

摘要

Most human leukocyte antigen (HLA) class I polymorphisms are focused on exons 2-4 (1). Several genetic mechanisms for HLA polymorphism generation have been proposed (2). Class I sequence alignment indicates that many alleles have clearly arisen by point mutation (1). In this report, we describe two new HLA class I alleles for HLA-B and HLA-C loci. Both showed a conventional serologic recognition. Subsequent sequence-based typing (SBT) analysis demonstrated the presence of novel alleles probably originated by point mutation events.