Acute cytomegalovirus infection as a transient risk factor for thrombosis: Report of three cases and focus on specific coagulation pathways

摘要

Cytomegalovirus (CMV) is a double-stranded DNA virus that belongs to the herpesviridae family. CMV infection is one of the most common infectious diseases, with a worldwide human seroprevalence between 60 and 100% [ 1 ]. Acute CMV infection is usually asymptomatic in immunocompetent patients or could lead in about 10% to a benign viral syndrome [2], However, severe manifestations, such as venous thrombosis, have been described and may be underestimated [3,4]. Moreover, several studies suggested a specific role of CMV in thrombus formation. Since venous thrombosis is a major cause of morbidity and mortality, the acknowledgment of risk factors is fundamental and could impact prevention and treatment strategies [5]. In this work, we report three cases of venous thrombosis associated with acute CMV infection in immunocompetent patients and discuss them in light of recent knowledge. Moreover, we synthesise the specific impact of CMV on coagulation pathways.