Several platelet receptors and their ligands are involved in platelet- dependent thrombus formation

摘要

I thank Drs. Kounis and Grapsas [1] for having read and commented my editorial [2] on the study by Shi et al, which showed that decreased platelet miR-223 expression is associated with high responsiveness to adenosine diphosphate (ADP) [3]. The findings by Shi et al are consistent with the demonstration that miR-223 regulates the expression of the platelet receptor for ADP, P2Y12 [4]. Because the patient population that was studied by Shi et al was on treatment with clopidogrel, which inhibits the platelet ADP receptor P2Y12, the authors concluded that decreased platelet miR-223 expression is associated with high on treatment platelet reactivity (HTPR) on clopidogrel, which was measured using 2 methods: the VASP phosphorylation assay and ADP-induced platelet aggregation (light transmission aggregometry). Therefore, if the results by Shi and collaborators will be confirmed by larger studies, low miR-223 expression could add to the long list of conditions that are associated with HTPR on clopidogrel [5,6].