Platelet adhesion in congestive heart failure

摘要

Introduction:Congestive heart failure is characterised by increased thromboemboiic events, stroke and sudden death. This may be related to a prothrombotic state, abnor mal thrombogenesis, endothelial damage/dysfunction and platelet abnormalities . An abnormal state of platelet activation may contribute to the pro-coagu lant state in congestive heart failure (CHF).The normal function of platelets includes adhesion to the sub-endothelial matrix, aggregation with other platelets, shape change and clot retraction . Several of these studies functions involve receptors on the platelet surface (such as gpllb/ Ilia) and interactions with matrix constituents (such as fibrinogen)