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Mechanisms of hormonal therapy related thrombosis

机译:激素治疗相关血栓形成的机制

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There is now compelling evidence that use of oral contraceptives and postmenopausal hormonal therapies containing various estrogens is associated with a weak, but clinically relevant risk of both arterial and venous thrombosis. The increased risk is related to type and dose of both estrogen and combined progestagen and mode of delivery. Treatment induces mainly subtle changes in individual components of the coagulation and fibrinolytic systems, but the overall effect is the induction of a prothrombotic phenotype. This brief review summarizes some of the mechanisms responsible the prothrombotic effects of such treatment. ? 2013 Elsevier Ltd. All rights reserved.
机译:现在有令人信服的证据表明,使用口服避孕药和绝经后的激素疗法(包含各种雌激素)与动脉血栓和静脉血栓形成的风险很小,但在临床上相关。风险增加与雌激素和孕激素联合使用的类型和剂量以及分娩方式有关。治疗主要引起凝血和纤溶系统各个组成部分的细微变化,但总的作用是诱发血栓前表型。这篇简短的综述总结了导致这种治疗的血栓形成作用的一些机制。 ? 2013 Elsevier Ltd.保留所有权利。

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