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Bronchial thermoplasty: Interventional therapy in asthma

机译:支气管热成形术:哮喘的介入治疗

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摘要

Bronchial thermoplasty is a new treatment option for patients with severe bronchial asthma who remain symptomatic despite maximal medical therapy. The aim of this interventional therapy option is the reduction of smooth muscle in the central and peripheral airways in order to reduce symptomatic bronchoconstriction via the application of heat. A full treatment with bronchial thermoplasty is divided into three bronchoscopies. Randomized, controlled clinical trials have shown an increase in quality of life, a reduction in severe exacerbations, and decreases in emergency department visits as well as days lost from school or work. The trials did not show a reduction in hyperresponsiveness or improvement in forced expiratory volume in 1 s. Short-term adverse effects include an increase in exacerbation rate, an increase in respiratory infections and an increase in hospitalizations. In the 5-year follow up of the studies available there was evidence of clinical and functional stability of the treated patients. Further studies are necessary to identify an asthma phenotype that responds well to this treatment.
机译:支气管热成形术是一种严重的支气管哮喘患者的新治疗选择,尽管经过最大程度的药物治疗,这些患者仍对症治疗。这种介入治疗选择的目的是减少中央和外周气道的平滑肌,以通过加热减少症状性支气管狭窄。支气管热成形术的完整治疗分为三个支气管镜检查。随机对照临床试验表明,生活质量提高了,严重恶化的程度降低了,急诊就诊以及因学校或工作而损失的工作日减少了。试验未显示1 s内高反应性降低或强制呼气量改善。短期不良影响包括病情加重,呼吸道感染增加和住院增加。在现有研究的5年随访中,有证据表明所治疗患者的临床和功能稳定。为了确定对这种治疗反应良好的哮喘表型,有必要进行进一步的研究。

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