Comments on 'Strategies for regeneration of the bone using porcine adult adipose-derived mesenchymal stem cells' by E. Monaco, M. Bionaz, et al. Theriogenology 2011;75:1381-99

摘要

In a recent issue of Theriogenology, we read the review by Monaco et al [1] focusing on strategies of bone regeneration using adipose-derived mesenchymal stem cells (ASCs) with great interest. We would like to comment on a concept presented by the authors that bone marrow mesenchymal stem cells (BMSCs) are incapable of craniofacial bone healing, whereas ASCs are capable (Page 1392, 2nd paragraph). In this review, the authors concluded from the studies of Meijer et al [2] and Leucht et al [3] that the inability of BMSCs to heal craniofacial bone defects is due to the different embryonic origin between the donor sites and recipient sites, i.e., flat bone is developed from the neural crest-derived skeletal stem cells while BMSCs have mesodermic origin.