Comments on 'Strategies for regeneration of the bone using porcine adult adipose-derived mesenchymal stem cells' by E. Monaco, M. Bionaz, et al. Theriogenology 2011;75:1381-99

摘要

We thank Yang et al. for pointing out a potentially misleading statement in our review. We agree with the authors that BMSC may successfully be used for craniofacial bone regeneration, as described by papers cited by the authors of the letter. The misleading statement in our review originates from a recent review we cited by Sensebé et al. 2010 [1]. In that review (page 97), the following statement appeared: “Although bone reconstruction with bone marrow MSCs is effective for long bones, bone marrow MSCs are not effective for jaw reconstruction [84]. This finding resulted from the neural crest origin of the facial skeleton, and although stem cells with a facial origin can differentiate into osteoblasts whatever the site of implantation, stem cells from bone marrow fail to differentiate into osteoblasts when implanted in the jaw [85].