The EP3-agonist sulprostone, but not prostaglandin E2 potentiates platelet aggregation in human blood.

摘要

Dear Sirs,Acute coroinuy syndromes, myocardial infarction and ischaemic stroke are leading causes of mortality and morbidity. Atherosclerosis, the basis for these diseases, has an important inflammatory component, and macrophages accumulating in atherosclerotic arteries produce prostaglandin E_2 (PGE_2), a major inflammatory mediator (1-3). Recently, it has been reported in mice that PGE_2 accumulating in inflammatory atherosclerotic lesions might contribute to atherothrombosis after plaque rupture (4).