TERMINATION OF UNWANTED PREGNANCY IN DOGS WITH THE DOPAMINE AGONIST, CABERGOLINE, IN COMBINATION WITH A SYNTHETIC ANALOG OF PGF2ALPHA, EITHER CLOPROSTENOL OR ALPHAPROSTOL

摘要

Associations of a dopamine agonist, cabergoline, and a synthetic analog of PGF2alpha, either alphaprostol or cloprostenol, were used to induce pregnancy termination in 15 mature Beagle bitches. Alphaprostol (20 mu g/kg/d) was injected subcutaneously (sc) in combination with cabergoline (1.65 mu g/kg/d, sc) daily for 5 d from Day 32 after the LH peak in 5 animals. Cloprostenol 2.5 mu g/kg/d in one group (n=5) and 1 mu g/kg/d in another group (n=5) was also used in combination with the same dosage of cabergoline, following the same protocol, but starting from Day 25 after the LH peak.