Pharmacokinetics of doxycycline in sheep after intravenous and oral administration

摘要

The pharmacokinetics of doxycycline were investigated in sheep after oral (PO) and intravenous (IV) administration. The IV data were best described using a 2- (n = 5) or 3- (n = 6) compartmental open model. Mean pharmacokinetic parameters obtained using a 2-compartmental model included a volume of distribution at steady-state (Vss) of 1.759 pl 0.3149 L/kg, a total clearance (Cl) of 3.045 pl 0.5264 mL/kg/min and an elimination half-life (t1/2o) of 7.027 pl 1.128 h. Comparative values obtained from the 3-compartmental mean values were: Vss of 1.801 pl 0.3429 L/kg, a Cl of 2.634 pl 0.6376 mL/kg/min and a t1/2o of 12.11 pl 2.060 h. Mean residence time (MRT0-[infinity]) was 11.18 pl 3.152 h. After PO administration, the data were best described by a 2-compartment open model. The pharmacokinetic parameter mean values were: maximum plasma concentration (Cmax), 2.130 pl 0.950 og/mL; time to reach Cmax (tmax), 3.595 pl 3.348 h, and absorption half-life (t1/2k01), 36.28 pl 14.57 h. Non-compartmental parameter values were: Cmax, 2.182 pl 0.9117 og/mL; tmax, 3.432 pl 3.307 h; F, 35.77 pl 10.20%, and mean absorption time (MAT0-[infinity]), 25.55 pl 15.27 h. These results suggest that PO administration of doxycycline could be useful as an antimicrobial drug in sheep.