Successful correction of D-lactic acid neurotoxicity (drunken lamb syndrome) by bolus administration of oral sodium bicarbonate

摘要

DRUNKEN lamb syndrome (DLS) has recently been described as lamb D-lactic acidosis syndrome (LDLAS). This syndrome occurs sporadically on farms and is seen in neonatal lambs demonstrating marked ataxia tending to recumbency. There is no clinical evidence of dehydration, but all cases show signs of severe metabolic acidosis characterised by significantly elevated D-lactate levels. Until now this syndrome has had a high mortality rate and treatment attempts have had little success.