Do not suspend levothyroxine

摘要

I have read Kenneth Bird's letter (PJ,6 November,p680) on his problems with an extemporaneous "suspension" of levothyroxine,using Keltrol,a polysaccharide gum,giving a neutral solution in water.Using only the information given in the package insert,Martindale and the Merck Index it should be obvious not to try to suspend this drug because of the low dose,and its relative ease of oxidation.In addition,levothyroxine has a significant solubility in water.