Antiretroviral regimens containing a single protease inhibitor increase risk of virologic failure in young HIV-infected children

摘要

Rifampin-based tuberculosis treatment can cause subtherapeutic concentrations of protease inhibitors and virologie failure in children receiving antiretroviral therapy. Among 217 children on antiretroviral therapy, tuberculosis cotreatment (in 78) was associated with virologie failure. Ritonavir-based single protease inhibitor antiretroviral therapy regimen predicted virologie failure (adjusted odds ratio 3.7, 95% confidence interval 1.5-8.9, P= 0.004) on multivariate analysis.