Antimalarial drug efficacy and resistance Threat and rapid decline in response rate to antimalarial drugs

摘要

Even a casual glance at the global malaria map produced by the World Health Organization gives cause for concern at the extent of spread of P. falciparum resistance to well-tried antimalarial drugs (chloroquine, sulfadoxine-pyrimethamine) and the specter of further spread of multidrug resistant parasite strains from their current enclaves in Southeast Asia and, to a lesser extent, South America (Figure 25).