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首页> 外文期刊>The Southeast Asian journal of tropical medicine and public health >INFECTION-ASSOCIATED HEMOPHAGOCYTIC SYNDROME AMONG PATIENTS WITH DENGUE SHOCK SYNDROME AND INVASIVE ASPERGILLOSIS:A CASE SERIES AND REVIEW OF THE LITERATURE
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INFECTION-ASSOCIATED HEMOPHAGOCYTIC SYNDROME AMONG PATIENTS WITH DENGUE SHOCK SYNDROME AND INVASIVE ASPERGILLOSIS:A CASE SERIES AND REVIEW OF THE LITERATURE

机译:登革热休克综合症和侵袭性细菌性肺炎合并感染性血细胞异常综合征的病例分析及文献复习

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摘要

The authors report four autopsy cases of previously healthy children with dengue shock syndrome complicated with infection-associated hemophagocytosis and invasive aspergillosis. Hemophagocytosis is confirmed by histopathology of autopsied reticuloendothelial organs. All four children were identified to have invasive aspergillosis by histopathology and three cases were positive on fungal culture for Aspergillus spp. Regarding the cause of death among the four children without pre-existing underlying disease, three cases were directly ascribable to invasive aspergillosis and the remaining case was ascribed to dengue shock syndrome. The transmigration of preexisting fungi from the respiratory mucosa damaged by the dengue shock process is postulated as the pathogenesis of invasive aspergillosis. The main predisposing factor was found to be prolonged dengue shock syndrome. We reviewed the clinicopathologic features and therapeutic management of infection-associated hemophagocytic syndrome in patients with dengue shock syndrome and invasive aspergillosis.
机译:作者报告了四例先前健康的登革热休克综合征并发感染相关的吞噬细胞和侵袭性曲霉病的儿童的尸检病例。通过尸检网状内皮组织器官的病理组织学证实了噬血细胞作用。通过组织病理学将所有四名儿童确定为侵袭性曲霉病,其中三例为曲霉属真菌培养阳性。关于四名没有预先存在基础疾病的儿童的死因,三例直接归因于侵袭性曲霉病,其余病例归因于登革热休克综合症。从登革热休克过程中受损的呼吸道粘膜转移已有真菌被认为是侵袭性曲霉病的发病机理。发现主要诱因是登革热休克综合征延长。我们审查了登革热休克综合征和浸润性曲霉病患者感染相关的噬血细胞综合征的临床病理特征和治疗管理。

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