~11C-Choline PET/CT in the primary diagnosis of prostate cancer: impact on treatment planning

摘要

Aim. Aim of the present study was to evaluate the usefulness of "C-choline PET/CT for detecting lymphatic or haematogenous spread and for planning radiotherapy in patients with medium-to-high risk prostate cancer.Methods. We have included 61 consecutive patients recently diagnosed with cancer prostate by biopsy. All patients were classified as medium-to-high risk: Gle-ason: 7-9; PSA: 6.5-50A ng/mL; stage T2c (N.=20) or stage T3 (N.=4l). Image acquisition began 5 min after intravenous injection of "C-choline (656+119 MBq), starting at the pelvis and continuing craniocaudally. Images were interpreted visually to evaluate uptake by the prostate gland. Lymph nodes with "C-choline uptake were considered invaded, regardless of their size. Bone lesions were considered positive when they showed greater focal uptake than the surrounding bone. In patients with evidence of lymph-node invasion or bone metastases (15 patients), disease was classified as locoregional, oligometastatic, or multimetastatic. Results. All patients had prostate gland uptake (20 focal, 8 bifocal, and 33 multifocal).