Rebuttal from Jeremy R. Beitler, Rolf D. Hubmayr and Atul Malhotra

摘要

More than a decade after low tidal volume ventilation for acute respiratory distress syndrome (ARDS) first gained widespread acceptance, it is still unknown how best to manage its effects on minute ventilation. High respiratory rate, or permissive hyper-capnia? Limiting respiratory rate has been shown in preclinical models to reduce lung injury even at a constant arterial CO2 tension (PaC02; Vaporidi etal. 2008). Curley and colleagues (2013) go one step further, making the case for additional benefit from hypercapnia during low tidal volume ventilation.