Food for thought - resveratrol vs. exercise training

摘要

Caloric restriction and exercise can both have what might be described in broad terms as anti-aging properties. Resveratrol, a polyphenol found most notably in red wine, can affect the deacetylase SIRT1 pathway and can mimic the positive effects of caloric restriction on inflammation, vascular function and metabolic regulation. Resveratrol is also a potent anti-oxidant and in some models anti-oxidants also slow age related declines in physiological function. Exercise training can have many of these same effects and one idea is that at least some of the positive effects of exercise, shared with caloric restriction, operate via its effects on SIRT pathways or by more generally countering the negative effects of 'oxidative stress' on a number of biological systems.