Exercise and diseased kidneys: are they compatible?

摘要

Regular endurance exercise is routinely recommended for primary and secondary prevention of cardiovascular disease due to its association with lower morbidity and mortality. The beneficial effects of regular exercise are well known and include improvements in cardiopulmonary function and reduction in coronary artery disease risk factors. Additionally, regular exercise has been shown to improve endothelial function in cardiovascular disease (Walfher et al. 2004) and healthy ageing (Seals et al. 2008). Maintenance of endothelial function is important for control of arterial tone in addition to numerous other beneficial effects, including inhibition of platelet aggregation, leukocyte adhesion, and smooth muscle cell proliferation. Acute exercise is associated with an increase in cardiac output and pulse pressure resulting in exercise-induced increases in shear stress. The increased shear stress is thought to be the stimulus for endothelial adaptations to exercise training (Walther et al. 2004; Green, 2009).