Supplementing exercise: Translational considerations for nutraceutical and lifestyle interventions

摘要

Ageing is the primary risk factor for cardiovascular diseases (CVD). With the unprecedented increase in the ageing population, the need for effective interventions and an understanding of their mechanism(s) of action is of utmost biomedical importance. Exercise elicits beneficial effects on cardiovascular health in older adults and is an important lifestyle intervention for the primary prevention of CVD. Preclinical studies suggest that the polyphenol resveratrol, a caloric restriction mimetic, potentiates the beneficial effects of exercise and may be a novel intervention for CVD prevention. Recently, Gliemann et al. (2013) conducted a translational investigation to assess the efficacy of concomitant resveratrol and exercise training for improving multiple markers of cardiovascular health including exercise capacity, functional performance and vascular function in older adults, as well as the mechanisms involved therein.