Phosphatidic acid: a novel mechanical mechanism for how resistance exercise activates mTORC1 signalling.

摘要

Resistance exercise and other models that promote skeletal muscle hypertrophy have clearly established an essential role for the mammalian target of rapamycin (mTORCl) pathway in regulating muscle protein synthesis and cell size (Baar & Esser 1999; Bodine etal. 2001). The rate of muscle protein synthesis is elevated following a single bout of resistance exercise and use of a specific mTOR inhibitor (rapamycin) can block the contraction-induced increase in protein synthesis in both rodents (Kubica et al. 2005) and humans (Drummond et al. 2009).