Mitochondrial biogenesis in adipose tissue: can exercise make fat cells 'fit'?

摘要

The training regimen produced predictable changes in body composition such that trained rats gained less weight and had . smaller fat pads than did sedentary rats. More importantly, Sutherland and colleagues demonstrated, for the first time in WAT, that exercise training increases PGC-lalpha (but not PGC-1beta) and Tfam mRNA expression, as well as COXIV and COREL Citrate synthase activity in the WAT of the healthy non-obese rats was also elevated in trained versus untrained animals. These changes were consistent in both epididymal and retroperitoneal fat pads, two separate visceral WAT depots. The authors proceeded to evaluate potential mechanisms governing these exercise-induced changes in WAT mitochondrial gene expression.