Giant-cell tumour (GCT) of bone is a rare primary bone tumour usually occurring in the long bones of young adults. The mechanisms of development of GCT of bone are not well understood and its biological behaviour is unpredictable. GCT of bone is typically benign and intralesional surgical resection is the treatment of choice. If done thoroughly, the patient may be cured in up to 90% of cases.1 But there are some cases of atypical GCT of bone; these might be tumours with multiple local recurrences, multicentricity, pulmonary metastases, or lesions that are impossible to remove surgically without causing substantial morbidity. Although there are reports of beneficial effects of bisphosphonates, to our knowledge, there are no successful prospective trials assessing a systemic therapy.
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