Fluoroquinolones such as ciprofloxacin and ofloxacin became the favoured drugs for the treatment of enteric fever in many regions following the emergence of organisms with multidrug resistance (to chlor-amphenicol, amoxicillin, and co-trimoxazole) in the early 1990s." Although fluoroquinolones were generally superior to cephalosporins such as ceftriaxone and cefixime, the spread of organisms with decreased susceptibility to ciprofloxacin or resistance to nalidixic acid has limited their effectiveness in much of Asia.23 The recent decline in prevalence of chloramphenicol resistance in many endemic areas has led to reconsideration of its use as an alternative to newer generation fluoroquinolones or azithromycin.
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