IT has been more than a decade since the sequencing of the human genome (1,2), and the decade anniversary is approaching for development of the HapMap project (3). During this decade, we have also seen the burgeoning of genome-wide association (GWA) studies (4). This special issue of the Journal of Gerontology Medical Science has aimed to assess what we have learned about associations between age-related health outcomes and specific genetic markers as well as more general genetic influences on aging. Summaries and synthesis of these findings are provided by leading researchers of model organisms and human populations.
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