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Higher inflammatory marker levels in older persons: Associations with 5-year change in muscle mass and muscle strength

机译:老年人中较高的炎症标志物水平:与肌肉质量和肌肉强度的5年变化相关

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Background. There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association, between serum levels of inflammatory markers and loss of muscle mass and strength in older persons. Methods. Using data on 2,177 men and women in the Health, Aging, and Body Composition Study, we examined 5-year change in thigh muscle area estimated by computed tomography and grip and knee extensor strength in relation to serum levels of interleukin-6 (IL-6), C-reactive protein, tumor necrosis factor-alpha (TNF-α), and soluble receptors (measured in a subsample) at baseline. Results. Higher levels of inflammatory markers were generally associated with greater 5-year decline in thigh muscle area. Most associations, with the exception of soluble receptors, were attenuated by adjustment for 5-year change in weight. Higher TNF-α and interleukin-6 soluble receptor levels remained associated with greater decline in grip strength in men. Analyses in a subgroup of weight-stable persons showed that higher levels of TNF-α and its soluble receptors were associated with 5-year decline in thigh muscle area and that higher levels of TNF-α were associated with decline in grip strength. Conclusions. TNF-α and its soluble receptors showed the most consistent associations with decline in muscle mass and strength. The results suggest a weight-associated pathway for inflammation in sarcopenia.
机译:背景。越来越多的证据表明,较高水平的炎症标记可能与老年人的身体衰退有关,这可能是由于炎症标记对肌肉的分解代谢作用所致。这项研究的目的是调查血清炎症标志物水平与老年人肌肉质量和力量丧失之间的关系。方法。根据《健康,衰老和身体成分研究》中2177名男性和女性的数据,我们检查了通过计算机断层扫描估计的5年大腿肌肉面积变化以及与白细胞介素6(IL- 6),C反应蛋白,肿瘤坏死因子-α(TNF-α)和可溶性受体(在亚样品中测量)在基线。结果。炎症标记物水平较高通常与大腿肌肉区域5年内更大的下降有关。通过调整体重5年的变化,除可溶性受体外,大多数关联都会减弱。较高的TNF-α和白介素6可溶性受体水平仍与男性抓地力下降更大有关。对体重稳定者亚组的分析显示,TNF-α及其可溶性受体水平升高与大腿肌肉区域5年下降有关,TNF-α水平升高与握力下降有关。结论。 TNF-α及其可溶性受体显示出与肌肉质量和力量下降最一致的关联。结果表明,与肌肉减少症的炎症相关的体重相关途径。

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